Heart disease: Why not protect all hormone therapies equally well

Heart disease: Why not protect all hormone therapies equally well

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Which form of hormone replacement therapy best protects against heart diseases?

What type of hormone therapy women get during menopause and in what form it is administered, according to current studies, seems to have a major impact on the accumulation of cardiac fat deposits and the likelihood of atherosclerosis. But which hormone therapy and what type of administration are recommended?

The current study by the North American Menopause Society (NAMS) found that oral CEE was more effective in reducing the increase in cardiac fat deposits and the associated risk of atherosclerosis than transdermal estradiol. The results of the study were published in the English-language journal "Menopause".

Health risks during menopause

As menopause changes, women become more likely to build more belly fat and visceral fat. This also increases the fat deposits around the heart. Such heart fat deposits have been associated with the progression of atherosclerosis, which also increases between perimenopause and postmenopause.

Benefits of hormone replacement therapy

Hormone therapy (or hormone replacement therapy) has been shown to slow the build-up of cardiac fat and the progression of atherosclerosis, depending on the type of hormone therapy and the type of administration. In the new study, the effects of horse conjugated estrogens (CEE) and 17β-estradiol were compared and compared with the oral and transdermal forms of administration. The effectiveness for the prevention of heart diseases should be determined.

Oral CEE or transdermal 17β-estradiol?

The researchers investigated how different types of hormone therapy and different types of administration affect the deposition of cardiac fat and the progression of atherosclerosis. Her goal was to find out how different forms of estrogen, particularly oral CEE and transdermal 17β-estradiol, affect the accumulation of cardiac fat and the progression of atherosclerosis, measured by the thickness of the lining of the carotid artery.

Benefits of oral CEE

According to the study results, oral CEE appears to slow the increase in paracardial adipose tissue better than transdermal estradiol. The study shows a clear effect of hormone therapy on the link between cardiac fat deposits and the progression of atherosclerosis, based on the type of estrogen or the mode of administration, the researchers of the North American Menopause Society report in a press release.

More research is needed

The research group concluded that further studies are needed to confirm whether these results are specific for oral CEE or for the oral route of administration. In the future, hormone therapies could be prescribed individually in order to optimize the benefits and minimize the risk. (as)

Author and source information

This text corresponds to the requirements of the medical literature, medical guidelines and current studies and has been checked by medical doctors.


  • Not All Hormone Therapy Protects Equally Against Heart Disease in Postmenopausal Women, North American Menopause Society, NAMS

Video: Prof. Robert Lustig - Sugar, metabolic syndrome, and cancer (September 2022).


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